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Large cohort analyses from the COPDGene cohort also showed that fSAD quantified by CT-PRM was common in subjects who had not yet developed airflow limitation diagnosed by spirometry and was associated with accelerated FEV 1 decline and adverse clinical outcomes during follow-up, which reinforced the value of imaging fSAD in early identification and risk stratification (83)

Heightened acute circulatory responses to smoking in women

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