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These results show that, in developing a reduced-toxicant cigarette design, a balance must be struck between the lower mainstream benzo[a]pyrene, aromatic amine and CO yields (as well as reduced sidestream yields) from reduced circumference cigarettes, and the increased volatile yields resulting from lower adsorbent incorporation

In some settings, nicotine or smoke-conditioned environments may also push macrophages toward dysfunctional immunosuppressive or M2-like states

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