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Nicotine belongs to a family of compounds called alkaloids and occurs naturally in several varieties of plant, including tomatoes, aubergines and potatoes, but is found at its highest levels in the tobacco plant

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The lesion appears thickened and corrugated, and as the condition worsens, it becomes more leathery.[3] Literature reveals that this condition has been established as a risk factor for developing oral carcinoma

British Doctors Study The British Doctors' Study was a prospective cohort study which ran from 1951 to 2001, and in 1956 provided convincing statistical evidence that tobacco smoking increases risk of lung cancer