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Studied by the same group of investigators, the presence of at least 1 G allele of TNFRSF18rs1061622 was shown to confer an excess risk of 49% for SLE in smokers 50

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Abnormal regional brain activity has been revealed in mesolimbic dopamine reward circuits, including the ventral tegmental area, nucleus accumbens, hippocampus, amygdala, cingulate, thalamus, striatum, and prefrontal cortex, as well as visuospatial attention circuits, including the dorsolateral and ventrolateral prefrontal cortex, parietal cortex, and extra-striate visual cortex in smokers 15, 16

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