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For the past 50-60 years, most of the driving factors have been replaced by behavioural risks including: excessive drinking, tobacco smoking, physical inactivity resulting in obesity
People with BD taking hepatic enzyme-inducing drugs such as carbamazepine, oxcarbazepine or topiramate have an increased nicotine metabolism, possibly resulting in the urge of heavier smoking and making it more difficulty to quit smoking (68)
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