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[59] Dilation or rupture (aneurysm) of ascending aorta [60] Cardiovascular autonomic dysfunction such as postural orthostatic tachycardia syndrome [61] [62] [63] Raynaud's phenomenon Varicose veins [64] Heart murmur Heart conduction abnormalities Urogynaecological [edit] Weakened connective tissues can lead to pelvic organ prolapse in female patients with EDS