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Although this paper has concentrated on the AMIS survey, the SHS survey does not appear to be immune from the phenomenon, although it is slightly less pronounced (SHS reporting discrepancy: 45.1%

As illustrated in Figure 2A, compared to channel 1 and 2, washing could remove some of the contaminating proteins

A paper of particular interest was from Mark Crosswhite of Juul Labs, who presented on non-targeted analysis challenges, and best practices focusing on the importance of scientifically based rationale for any decisions made during the execution and analysis of non-targeted studies

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