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For the present observational analysis of baseline trial data, assuming a 5.0% significance level (alpha), an anticipated overall prevalence of tobacco use of 7.6% 6 , and a clustering-related design effect of 1.59, with a precision of 2% (95% confidence interval width) and 80.0% power to detect a relative risk as small as 2.1 when one-third of the sample is in an exposed group and the comparison prevalence of tobacco use is 5.0%

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