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Despite these crucial topics that were addressed, there are some limitations to this review, which include that no meta-analysis was performed and a systematic review was not conducted, as this is a narrative review on the focused topic of challenges related to the toxicity assessment of emerging inhalable tobacco products

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for instance that lung cancer rates were found higher in non-inhalers than in heavy smokers because of subtle interactions between the amounts smoked, the tar/nicotine yield of the cigarette, and the style of smoking [123]

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