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Probably this is because all the carcinogens and cardiac toxins in tobacco smoke have not been identified and because there are likely interactions between the different constituents in the complex mixture that cigarette smoke represents

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The degree of enzyme induction shows significant inter-individual variability and may be dose dependent, with one study demonstrating dose-dependent increases in CYP1A2 induction with increases in number of cigarettes smoked per day [8], [9]