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While moist snuff continues to dominate volume, tobacco-free and nicotine-free "chews" are emerging as high-growth segments among younger demographics and those seeking smoking cessation aids

and species of the genera Alistipes, Bacteroides, Eubacterium, and Roseburia

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In a 6-month clinical study in the USA, smokers who switched from smoking cigarettes to predominant THS use showed significant improvements in clinical risk endpoints associated with O 2 delivery (decreased carboxyhaemoglobin levels), inflammation (reduced white blood cell count), and COPD (increased FEV 1 ), although their plasma nicotine levels remained similar to that in smokers