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Additionally, NMDARs, which influence both glutamate and GABA, highly influence dopamine synthesis and transmission (75, 87)

Surely the danger posed to the smoking masses was not the mild and soothing weed, he wrote, but the organized creation of states of frantic alarm. Fisher was a well-known hothead (and an inveterate pipe smoker), but the letter and the resulting debate, which lasted until his death in 1962, was taken as a serious critique by the scientific community