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The cause is not completely understood but involves a T cell-mediated immune response triggered by a variety of factors which may include nutritional deficiencies, local trauma, stress, hormonal influences, allergies, genetic predisposition, certain foods, dehydration, some food additives, or some hygienic chemical additives like SDS (common in toothpaste)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Clapp PW, Pawlak EA, Lackey JT, Keating JE, Reeber SL, et al

Use of the ISRM relies on assumed background concentrations of air pollutants that may change over time 48 , particularly under scenarios in which the grid is aggressively decarbonized and vehicles are electrified