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Main Outcomes and Measures Incident CVD (myocardial infarction, stroke, heart failure, or cardiovascular death)

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These geographic factors illustrate the complexities in a chronic disease entity like IBD, with a multifactorial etiopathogenesis and multiple, relatively weak predictive associations of disease prognosis, in assessing whether a variable such as smoking status truly has an independent, significant impact on disease course and/or treatment outcomes

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