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A meta-analysis of over 100 trials concluded that varenicline was just over twice as effective as nicotine replacement therapies and bupropion in helping patients quit (Mills EJ et al, Harm Reduct J 2009;6:25)

The stems and root systems are strong enough that the plants can lean at severe angles without toppling over or requiring staking, although branches can break at the base in strong storms or under very windy conditions