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Is the sense of depression felt after quitting being caused by chronic organic depression that was being masked, hidden or diminished by one or more of cigarette smoke's more than 4,000 chemicals (most notably nicotine), or possibly due to smoke's 4,000 chemicals interacting with current medications being taken, or does it reflect the normal and expected temporary sense of loss associated with ending a long and extremely intense chemical relationship

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Among those who were smoking daily at follow-up, 54.7% (n=706) reported intentions to quit although only 4.1% (n=53) intended to quit within the next 30 days, and 36.3% (n=469) had attempted to quit in the past 12 months

The absence of combustion is why HTP use is harm reduction