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Conclusions and perspectives CS imposes widespread systemic consequences not only through its direct toxicological insults but also by reshaping microbial ecosystems that are fundamental to host homeostasis

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We obtained surface PM 2.5 measurements in Canada from Environmental Canada ( We obtained PM 2.5 measurements in the USA from the US Environmental Protection Agency (US EPA) AirNow ( and from the Interagency Monitoring of Protected Visual Environments (IMPROVE) ( To improve the representation of air pollution, we also collected PM 2.5 monitoring data from: the AirFire programme of the US Forest Service ( for the USA

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