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Measurement of exposure: tobacco product use To evaluate the association between past tobacco product use, combustible cigarette use, HTP use, and combined use compared to never smokers, this study defined specific exposures aimed at clearly differentiating each smoking status

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Therapeutic approaches include promoting mitochondrial fusion through agents like leflunomide, which enhances the function of Mfn2, a key protein in mitochondrial fusion (Miret-Casals et al., 2018)