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In addition, several studies have evaluated optimal models for HCV treatment within harm reduction and opioid treatment programs.[10,38,39] One large study (HERO study) conducted in eight opioid treatment programs and 15 community health centers randomized 755 individuals to sofosbuvir-velpatasvir plus patient navigation or sofosbuvir-velpatasvir plus modified directly observed therapy (mDOT).[10] Although there was slightly higher adherence to sofosbuvir-velpatasvir in the mDOT arm, there was no difference in SVR12 rates, with 60% and 91% of patients in the mDOT arm and 62% and 93% of patients in the patient navigation arm achieving an SVR12 in the intention-to-treat analysis and per-protocol analysis, respectively.[10] Potential Reinfection with HCV among Persons who Inject Drugs Multiple studies have shown a significant risk of HCV reinfection in persons cured with HCV therapy