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These observations align well with the concept of Anna Karenina principle for animal microbiomes (Zaneveld et al., 2017), which refer to a more variable microbial community composition in dysbiotic individuals compared to healthy individuals

Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA) requires states to effectively enforce laws prohibiting the sale and distribution of tobacco products to persons under the age of 21

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