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When one or more of these organs malfunctions, the eyes can turn yellow: Liver Gallbladder Pancreas Other Possible Reasons for Yellow Eyes There are several diseases and conditions that can cause yellow eyes, such as: Hepatitis Gallstones Drinking too much alcohol Taking certain medicines Liver infection A reaction to a blood transfusion Sickle cell anaemia Malaria Cirrhosis Symptoms of Yellow Eyes The main symptom of yellow eyes is, unsurprisingly, the yellowing of the whites of the eyes