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Available from: Cohen I, Garis L, Rajabali F, Pike I

We used locally weighted regression and smoothing because both visual inspection and analysis of residuals using a preliminary linear regression indicated a nonlinear relationship between odds of disease progression and mean or median age reported in each study

At the time of the amendments, it was mentioned that E-Cigarettes and nicotine-free products would be included in the future

"We came up with a lot of anecdotal evidence from patients saying that these are very helpful, but it's mostly surveys and the data is skewed, because people who have a positive experience are more likely to report back," she says