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Exclusion criteria Patients who did not meet the definition of current smoking with poor compliance (missing 3 follow-up visits or having a medication adherence rate 30% missing data for key variables

The monoclonal antibodies of Herceptin or Trastuzumab can be loaded onto PVX nanofilaments, which successfully induced apoptosis in breast cancer cell lines ( The tumor microenvironment poses a great challenge to immune clearance by virtue of being immunosuppressive and favoring immune escape of the tumors through the inhibition of anti-tumor T-cells ( The icosahedral shape of CPMV capsid can be loaded with precise drug cargos to target tumor and cancer cells