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Although this supports the biological plausibility of tissue injury and disease from long-term exposure to e-cigarette aerosols, generation of reactive oxygen species and oxidative stress induction is generally lower from e-cigarettes than from combustible tobacco cigarette smoke

The following effects may be experienced: difficulty sleeping and exhaustion headaches, dizziness and blurred vision paranoia, hallucinations and confusion irritability and feeling down 1,6 Using depressant drugs such as alcohol, benzodiazepines or cannabis to help with the come down effects may result in a cycle of dependence on both types of drugs

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