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One of the earliest uses in a semi-modern sense was Francis Bacons Novum Organum (1620), where he frequently mentions laws, as in It is best to consider matter, its conformation, and the changes of that conformation, its own action, and the law of this action or motion ; Nicolai Stenos 1669 principles of stratigraphic superposition are sometimes referenced as Laws, but he did not use the Latin equivalent lex

Comparison of nicotine patch alone versus nicotine nasal spray alone versus a combination for treating smokers: A minimal intervention, randomized multicenter trial in a nonspecialized setting

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