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Now this one may seem counter-intuitive, but be sure to close off any interior air vents

The paper also demonstrates how the tobacco industry has used intensive marketing to popularize menthol cigarettes, especially in Black communities, and to encourage use of menthol-flavored products among youth

The chemicals in cigarette smoke damage blood vessels, leading to atherosclerosis (hardening and narrowing of the arteries) and an increased risk of blood clots

The Winix 5500-2 will work well for your application though if you're especially concerned about the gaseous components of the smoke I would recommend the Austin Air HealthMate.