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In SVG-A astrocytes, the nicotine-mediated increase in intracellular ROS levels was partially prevented by the inhibition of cytochrome P450 2A6 enzyme with tryptamine (Ande et al

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Once dilation of the atria has occurred, this begins a chain of events that leads to the activation of the reninangiotensinaldosterone system (RAAS) and subsequent increase in the matrix metalloproteinases and disintegrin, which leads to atrial remodeling and fibrosis, with loss of atrial muscle mass