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18 The usual duration of treatment is 12 weeks and for those who have quit successfully at the end of treatment, a second course of 12 weeks can be prescribed to reduce relapse

Weak instruments (i.e., weak association with the risk factor and/or imprecise association with the outcome), horizontal pleiotropy (when genetic IVs affect the outcome through causal pathways unrelated to the exposure), heterogeneity in variant-specific effects, and errors in phenotype measurements (especially if these are biased) can limit applicability [20]

Researchers tested three different measures: strength of urges to smoke, confidence in staying quit, and cessation fatigue (the mental exhaustion from maintaining abstinence)

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