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On the y -axis of the heat map, the 99 chemicals were ranked by their safety classification (Toxic, Harmful, Irritant, and No data) as posted on the Good Scents Flavor Company website 17 , which provides peer-reviewed information for the flavor, food, and fragrance industry

Tobacco production uses more water and wood, and has more pesticides applied to it, than most other crops , further affecting water supplies and contamination of the soil

With scientific consensus still forming and regulation limited, the industry had considerable freedom in how it presented its products