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Recent studies have focused on: Mechanism of Toxicity Researchers have identified that diacetyl's toxicity stems from its ability to cross-link proteins in lung tissue, leading to the inflammatory cascade that results in bronchiolitis obliterans

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As early as 1964, Radford and Hunt hypothesized that the presence of 210 Po in tobacco smoke, and its preferential localization in the bronchial epithelium, would be a cause of lung cancer 5,13

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