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The exact nature and extent of brain damage or other lasting effects can depend on a number of factors including: Age Frequency of use Strength of the dosage Pre-existing mental illness or genetic predisposition to mental illness Though marijuana may not be as overtly damaging as alcohol, meth, or cocaine (substances that drastically alter brain chemistry and uncoincidentally, are highly addictive), there are still plenty of undesirable cognitive side effects to be had

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