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This is the first study to take a deep look at whether switching to a less harmful nicotine source can be maintained over time without relapsing to cigarette smoking, said Pierce
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Response to Reviewer 1s comment 4 : We provided more detailed information related to Reviewer 1s Comment 4 showing that the observed decline in cigarette smoking prevalence accompanied with an increase in IQOS/HTP prevalence over the three study years, in Japan is supported by independent data
And so in the 1970s, a chewing gum that contained nicotine was introduced and it was offered as a prescription method to assist people in quitting their habit
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