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The variable numbers of necrotic keratinocytes revealed by histopathology suggest that blister formation may be the result of a phototoxic reaction,7,8 while the near exclusive location of the lesions on the lower limbs suggests that friction and trauma may trigger lesion formation.8 Heidbreder and Henseler5 demonstrated that PUVA treatment inhibits the synthesis of connective tissue and increases collagen fractionation, resulting in a loss of dermoepidermal cohesion

After three to four weeks at the latest, the body has overcome the nicotine addiction

The Guardian's readers debate whether it came from a mispronunciation of "the force" or a quick way to say "the Feds," but it first emerged in the 1920s and 1930s and was later popularized with 1960s protest culture

However, its effects may be more pronounced in some