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One NIH Study found moderate evidence of a statistical association between cannabis use and the development of substance dependence and/or a substance abuse disorder for substances, including alcohol, tobacco, and other illicit drugs. Addiction within the family, especially during early childhood, may also cause a person to develop an addiction

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Chronic and acute tolerance to the heart rate effects of nicotine

26:73140 [DOI] [PubMed] [Google Scholar] 97.Spillane JF