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This makes it seem like youre higher but that high goes away once the oxygen is flowing to your brain again. As per mentioned by this user, when holding your breath in order to keep smoke in, you deprive your brain from oxygen

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Current Intelligence Bulletin 62

cMRTP aerosols with significantly reduced effects on both key mechanisms involved in cancer causation hypothesized by Balkwill and Mantovani ( genetic damage and inflammation ) [24] would be reasonably expected to also reduce the risk of lung cancer compared with cigarette smoking