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Smoking cessation may also increase the concentration of other drugs partially metabolized by the CYP1A2 enzyme, such as imipramine, olanzapine, clomipramine, and fluvoxamine, although data are limited and the possible clinical significance is unknown

These enticing flavors along with the new, more powerful delivery devices have provided a high dose of nicotine addicting our youth at rates we've never seen. Frank Orton, who owns a small chain of convenience stores and gas stations in northern Minnesota, said if stores follow the law and sell to people 21 and older, people of age should be free to make their own choices