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Cardiovascular diseases: Nicotine impacts the circulatory system by causing irregular heartbeats, high blood pressure, an increased risk of heart attacks, and coronary artery spasms

In some contexts, it exerts anti-inflammatory effects, such as reducing cytokine activity in ulcerative colitis

The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) identifies tobacco use disorder with criteria including cravings, difficulty reducing usage, and withdrawal symptoms like anxiety and restlessness when nicotine intake is reduced

Nora Volkow, Director of the National Institute on Drug Abuse, tobacco use is a major contributor to morbidity and mortality, causing approximately 440,000 deaths annually in the United States