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Together, these findings indicate that smoking even a small number of cigarettes per day has substantial negative health effects and provide further evidence that smoking cessation benefits all smokers, regardless of how few cigarettes they smoke. About the National Cancer Institute (NCI): NCI leads the National Cancer Program and the NIHs efforts to dramatically reduce the prevalence of cancer and improve the lives of cancer patients and their families, through research into prevention and cancer biology, the development of new interventions, and the training and mentoring of new researchers

It also increased catalase activity in the lung and resulted in changes in the level and mRNA of major matrix metalloproteinases (MMP-1, MMP-9, and MMP-12), confirming pulmonary damage associated with hookah use [117, 118]

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