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The cause of this disruption to the oral microbiome has a number of possible explanations

Lack of Pharmacological Treatment Unlike opioid or alcohol use disorder, no FDA-approved medications exist for cocaine addiction: Treatment relies entirely on behavioral interventions No medication to reliably reduce cravings or block effects Emerging treatments (immunotherapy, dopamine agonists) remain in research phases 4

In addition, indepth biological research on the modes of action of related SNPs will help reveal the specific pathways through which smoking behavior affects liver health and provide a stronger basis for personalized intervention measures

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