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One of the most popular examples is the nicotine patch, a small patch that adheres to the skin and releases small amounts of nicotine to help you manage withdrawal symptoms

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The trial was not randomized and controlled, and thus causality cannot be determined, partly because of an unexpectedly high cessation rate which resulted in a control group without sufficient power

In addition, e-cigarettes downregulate the expression of genes related to ciliary assembly and motility ( DNAH10 and FOXJ1 ), leading to a reduction in airway epithelial ciliated cells [78]