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Over time, regular nicotine use can lead to increased levels of anxiety, as users rely on it to feel calm, but the underlying anxiety issues remain unresolved

Further, at a state level, these results show that there are similar declines apart from NT, where the direct estimates are considerably unstable (shown by wide confidence intervals), although the model-based estimates provide smoother trends (bottom panel plots in Figure 2)

It affects cardiovascular, endocrine, and immune functions