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Performance and Reporting Resources Guidance Tobacco Compliance Webinars for Manufacturers and Importers Reference Tools Guidance: Principles for Designing and Conducting Tobacco Product Perception and Intention Studies Modified Risk Tobacco Product (MRTP) Application Review Process: Presentation from 2018 Tobacco Product Application Review Public Meeting Tobacco Product Application Review: Modified Risk Tobacco Product Applications: Presentation from 2018 Tobacco Product Application Review Public Meeting Information and Resources on Application Review Programs: Presentation from 2018 Tobacco Product Application Review Public Meeting CTP Electronic Submissions Standards and Activities: Presentation from 2018 Tobacco Product Application Review Public Meeting TPSAC Meetings on MRTP Applications Perspective: Lessons Learned from the First Review of Modified Risk Tobacco Product (MRTP) Applications Publicly Available MRTP Application Materials FDA makes redacted MRTP application materials available for public comment in accordance with applicable laws

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Cell culture Human primary T cells were cultured in X-Vivo 15 medium (Lonza) supplemented with 10% human heat-inactivated serum (Fisher), 10 ng ml 1 interleukin (IL)-7 (Miltenyi) and 10 ng ml 1 IL-15 (Miltenyi) at 37 C with 5% CO 2

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