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Additional R packages, including ComplexHeatmap for heatmap visualization, ggpubr for statistical annotation, pheatmap for hierarchical clustering heatmaps, and cowplot for figure arrangement, were utilized as needed

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Engaging strategies used in marketing (eg, trend watching), surveillance of social media and search trend analysis also may prove valuable.130132 More rapid surveillance is criticallarge, national surveys with cumbersome systems for adding or changing questions are too slow to provide timely data on an actively changing marketplace

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