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Notably, IL-31RA expression is regulated by STAT3 within sensory neurons and remains elevated even after clinical resolution of inflammation, suggesting a pruritic memory mechanism that enables sustained neuronal activation independent of primary inflammatory cues (40)

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Stymied by SCDP's inability to get a meeting with any new client since losing Lucky Strike, he came out against Big Tobacco with a full-page ad in the New York Times, announcing that, since smoking was bad and bad for you, the firm would no longer be taking on tobacco clients