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Most of these estimations do not use factual data (other than PM2.5 levels) from the studied location with no attempt to modulate the impact of air pollution on mortality (ex: data is often calibrated in cities where industrial, traffic and urban pollution is potentially considerably more toxic than biomass burning or desert dust)

The agency is tasked with determining whether these products have a benefit to adult smokers sufficient to overcome the public health threat posed by the well-documented, alarming levels of youth use of such products. Flavored ENDS products are extremely popular among youth, with over 80% of e-cigarette users between ages 12 through 17 using one of these products, said Mitch Zeller, director of the FDAs Center for Tobacco Products

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