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Early Abstinence Time: 2 weeks-3 months post-quitting Mental addiction turns out to be the largest obstacle, which occurs due to stress or habits
The central nicotinic cholinergic receptors, namely the low affinity 7 and the high affinity 42 nicotinic receptors located in the ventral tegmental area (VTA), are stimulated by nicotine resulting in a rapid release of dopamine in the nucleus accumbens, mediating the rewarding and reinforcing effects of nicotine (25) (Figure 1)
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