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Exposure to cigarette smoke is also an important modifiable environmental risk factor for MS development and its clinical course ( The population attributable fraction (AF) of disease due to exposure, or the proportion of the disease in a population attributable to smoking, can be used to assess the contribution of smoking to the risk of disease development

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In the sensitivity analysis utilizing relative risks of smoking initiation and cessation without weighting by subpopulation size ( vii ), the difference in time needed to reach 5% smoking prevalence increases by 8 years between low SES and higher SES subpopulations and 11 years between SPD and non-SPD subpopulations (Additional File 1, Supplementary Fig

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