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Chronic exposure changes brain chemistry which can result in dependence and withdrawal symptoms

"While no one is claiming the Marlboro Man is heading for his last roundup, there is a widespread belief that the imagery, once fresh and compelling, has become dated." In 1992, Wayne McLaren became the first man who appeared in a Marlboro advertisement to die of a smoking-related illness

According to the Penn State E-cigarette Dependence Index classification, of the total current e-cigarette users (n=892), 41.3% (n=368) were classified to have low dependence, 26.9% (n=240) to have medium dependence, 16.6% (n=148) have high dependence, and 15.2% (n=136) were determined to have no dependence

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