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I never liked Beetlejuice

The women marching held cigarettes as markers of liberation, and the New York Times headline the next day read "Group of Girls Puff at Cigarettes as a Gesture of Freedom." The march was a success, solidifying the image of cigarettes as "torches of freedom" within the feminist movement

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Briefly, human in vitro systems do not reflect all aspects of cellular interaction and tissue organization, in vivo animal models do not necessarily reflect human biology in its finer details, and human clinical studies are hampered by time and cost constraints as well as accessibility to key biological samples (that are accessible in animal studies)