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It has been demonstrated that EXs play a key role in intercellular communication by carrying biomolecules, including proteins, DNA, miRNA and lncRNA, involved in cell communication, migration, angiogenesis, and proliferation [100]

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thus, nicotine slows the movement of food through these parts worsening symptoms when exposed for too long under the acidic environment such as prolonged exposure to gastric juices containing high amounts of acidity produced by our bodies after eating fatty meals or drinking alcohol excessively

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